【摘要】 为了比较不同放疗方式对非小细胞肺癌(NSCLC)脑转移的疗效及预后影响因素,回顾性分析97例NSCLC脑转移患者的临床资料。23例接受全脑放疗2周30 Gy/10次(A组);45例接受全脑放疗4周40 Gy/20次(B组);29例接受全脑放疗4周40 Gy/20次,然后局部缩野加量1周10 Gy/5次(C组)。A组中位生存时间8.7个月,1年局部控制率为23%;B组中位生存时间8.8个月,1年局部控制率为63%;C组中位生存时间9.2个月,1年局部控制率为84%。3组中位生存时间差异均无统计学意义(P>0.05),但C组1年局部控制率明显高于A组。单因素分析表明,颅外转移及脑转移瘤个数是预后的危险因素;多因素Cox模型分析表明,颅外部位转移是预后的独立危险因素。初步研究结果提示,NSCLC脑转移的预后与颅外转移及脑转移瘤个数有关,颅外转移是影响预后的独立因素。更多还原

【Abstract】 The objective of this study was to compare the efficacy of different radiation options in non-small cell lung cancer(NSCLC) patients with brain metastasis,and study its prognostic factor.Retrospective analysis of 97 NSCLC patients with brain metastases was carried out.Group A including 23 cases received whole brain radiotherapy 30 Gy/10 f while Group B 45 cases receiving whole brain radiotherapy 40 Gy/20 f.Group C including 29 patients received whole brain radiotherapy 40 Gy/20 f,and then increased by 10 Gy/5 f to partially reduced field.The median survival time was 8.7 months,and 1-year local control rate was 23% in Group A while in Group B 8.8 months and 63%,in Group C 9.2 months,and 84% respectively.There was no significant difference in median survival time among three groups(P>0.05).However,the 1-year local control rate of Group C was significantly higher than that of Group A.Univariate analysis showed that metastasis outside of the brain and the number of metastases in the brain were the prognostic factors.Multivariate Cox model analysis showed that metastasis outside of the brain was independent prognostic factor.In conclusion,in NSCLC patients with brain metastases,both metastasis outside of the brain and number of metastases in the brain have correlation with prognosis.Metastasis outside of the brain is independent prognostic factor.更多还原