【摘要】 目的:探讨环氧化-酶2(COX-2)、表皮生长因子受体(EGFR)在胸腺瘤组织中表达的生物学意义及其相互关系。方法:采用免疫组织化学SP法,检测53例胸腺瘤患者中COX-2、EGFR的表达,用5例正常胸腺组织作对照。结果:53例胸腺瘤组织中,随着Masaoka分期进展,COX-2、EGFR阳性表达率逐渐升高,差异有统计学意义,χ2值分别为7.283和5.330,P值分别为0.007和0.021。COX-2和EGFR的阳性表达率与胸腺瘤的Masaoka分期及淋巴结转移等参数有关,P<0.05;与胸腺瘤组织学分型无关,P>0.05。COX-2与EGFR的表达呈正相关,r=0.811,P<0.01。结论:胸腺瘤的浸润性发展与COX-2及EGFR的增强表达具有相关性,COX-2及EGFR在肿瘤细胞的增强表达可作为胸腺瘤恶性度和判断预后的重要生物学指标,并可为临床医生提供诊断和辅助治疗依据。更多还原

【Abstract】 OBJECTIVE:To investigate the biological significance and relationship between COX-2 and EGFR expression in thymoma tissues.METHODS:The immunohistochemistry method was employed to detect the expressions of COX-2 and EGFR in 53 cases of thymoma,and 5 cases of normal thymus were as the control.RESULTS:The expressions of COX-2 and EGFR significancly increased along with the advance of thymoma Masaoka stage(χ2 were 7.283 and 5.330,P were 0.007 and 0.021).There was a significance relationship between the expressions of COX-2 and EGFR and lymphoid node metastasis(P<0.05),but no relevance with the thymoma histology(P>0.05) The expressions of COX-2 and EGFR had a positive correlation(r=0.811;P<0.01).CONCLUSIONS:There is a positive correlation between the COX-2 and EGFR expressions and the advance of Masaoka stage.The increasing expressions of COX-2 and EGFR can be a important biological parameters to maligiancy and prognosis for thymoma,and can provide the evidence for diagnosis and adjunctive therapy.更多还原