【摘要】 目的:探讨碱性成纤维细胞生长因子(bFGF)在鼻咽癌组织中表达及其与鼻咽癌浸润转移的关系。方法:采用SP免疫组化法,检测127例鼻咽癌标本和60例鼻咽黏膜慢性炎症组织中bFGF的表达。结果:鼻咽癌组bFGF阳性表达率为78.0%,鼻咽黏膜慢性炎症组无阳性表达,两组比较差异有统计学意义,P<0.05;远处转移组bFGF阳性表达率为89.7%,显著高于无远处转移组的72.7%,两组比较差异有统计学意义,P<0.05。结论:bFGF在鼻咽癌组织中有高表达,参与了鼻咽癌发生发展、浸润转移等生物学行为。bFGF可以作为评价鼻咽癌恶性程度的1个新型指标,来预测鼻咽癌的侵袭转移情况及患者的预后。更多还原

【Abstract】 OBJECTIVE:To study the expression of basic fibroblast growth factor (bFGF) in nasopharyngeal carcinoma (NPC) and effects on tumor invasion and metastasis. METHODS: The bFGF expression from 127 cases of NPC and 60 cases of chronic inflammation of nasopharyngeal mucosa were detected by SP immunohistochemical method. RESULTS: The bFGF positive rate of the NPC group was 78.0%, there was no expression of chronic inflammation of nasopharyngeal mucosa group, compared the different was significant (P<0.05); The bFGF positive rate of distant metastasis group was 89.7%, the no distant metastasis group was 72.7%, compared the different was significant (P<0.05). CONCLUSONS: The bFGF has high expression in NPC, bFGF involve in the development of NPC, the biological behavior of invasion and metastasis. The bFGF can be used as an new indicator for evaluation of NPC to predict the tumor invasion, metastasis and the prognosis of patients.更多还原