【摘要】 目的探讨慢性阻塞性肺疾病(COPD)患者血清及诱导痰中肿瘤坏死因子α(TNF-α)水平测定的临床意义。方法采用酶联免疫吸附(ELISA)法监测30例COPD患者治疗前及治疗1、3、6、12、24个月血清和诱导痰中TNF-α的动态变化,同时记录圣.乔治问卷(SGRQ)评分。结果患者治疗前及治疗1、3、6、12、24个月血清及诱导痰TNF-α比较,差异均有统计学意义(P<0.05)。患者治疗前及治疗1、3、6、12、24个月SGRQ评分比较,差异有统计学意义(P<0.05)。血清中TNF-α与SGRQ评分呈正相关(P<0.05);诱导痰中TNF-α与SGRQ评分呈正相关(P<0.05)。结论 COPD患者病情与血清及诱导痰中TNF-α具有相关性,TNF-α水平反映COPD气道炎症的变化过程。TNF-α可作为COPD患者病情预测及指导预后的指标。更多还原

【Abstract】 Objective To investigate the clinical significance to determine the tumor necrosis factor α (TNF-α) levels in serum and sputum of patients with chronic obstructive pulmonary disease (COPD).Methods The enzyme-linked immunosorbent assay (ELISA) was used to monitor dynamic changes of TNF-αin serum and induced sputum of 30 COPD patients before treatment and 1,3,6,12,24 months after the treatment.St George′s respiratory questionnaire(SGRQ)score was also recorded.Results There was significant difference in levels of serum and induced sputum of the patients before treatment and 1,3,6,12,24 months after the treatment (P<0.05).There was significant difference in SGRQ score of the patients before treatment and 1,3,6,12,24 months after the treatment (P<0.05).Serum TNF-α and the SGRQ score was positively correlated (P<0.05);and so was induced sputum TNF-α and the SGRQ score (P<0.05).Conclusion The condition of COPD patients is correlated with the levels of serum and sputum TNF-α,and the TNF-α level reflects the change of airway inflammation of COPD.So TNF-α can be used as an index to predicate the condition and determine the prognosis for COPD patients.更多还原