【摘要】 目的比较地塞米松与低分子右旋糖酐治疗急性胰腺炎时单独及联合用药的疗效。方法 124例患者随机分为对照组、地塞米松组、低分子右旋糖酐组以及地塞米松与低分子右旋糖酐联合应用组(联合用药组),每组31例。地塞米松组及低分子右旋糖酐组分别在对照组治疗基础上加用地塞米松或低分子右旋糖酐,联合用药组同时使用低分子右旋糖酐与地塞米松。结果低分子右旋糖酐组、地塞米松组、联合用药组的疗效明显优于对照组(P<0.01),且联合用药组优于低分子右旋糖酐组及地塞米松组(P<0.01),地塞米松组与低分子右旋糖酐组疗效比较差异无统计学意义(P>0.05)。结论在常规治疗基础上加用地塞米松或低分子右旋糖酐可显著改善急性胰腺炎病程进展,联合使用效果更好,可缩短病程,减轻病情。更多还原

【Abstract】 Objective To compare the individual and combined therapy effects of dexamethasone(DXM) and dextran-40 on treatment of acute pancreatitis on the basis of the control group.Methods 124 cases of patients were randomly divided into control group,DXM group,dextran-40 group,and the combination group treated by DXM and dextran-40,with each group 31 cases.DXM and dextran-40 groups were treated with DXM or dextran-40 respectively in addition to the treatment of the control group,with the combination group using the dextran-40 and dexamethasone at the same time.Results Efficacy of the dextran-40 group,DXM group and combination group is significantly better than that of the control group(P<0.01),and the efficacy of combination group was better than that of the dextran-40 group and dexamethasone group (P<0.01),and there was no significant difference between the efficacy of dexamethasone group and dextran-40 Group(P>0.05).Conclusion Adding dexamethasone or dextran-40 on the basis of conventional therapy can significantly improve the progression of acute pancreatitis,while the combination of dexamethasone and dextran-40 can shorten the course and alleviate the disease.更多还原