【摘要】 目的:探讨西宁地区人群中常见因素对血清胃泌素水平的影响,提示血清胃泌素在胃癌及其癌前疾病诊断中的价值。方法:利用ELIS方法检测2006年1月—2009年6月收集的781份血清样品的血清胃泌素水平。结果:≥60岁组的血清胃泌素水平显著高于其他年龄组(P<0.01)。患者胃窦疾病患者的血清胃泌素水平显著高于患有胃体疾病患者(P<0.01)。HP阳性组的血清胃泌素水平显著高于HP阴性组(P<0.01)。由正常者经浅表性胃炎至胃糜烂或溃疡,血清胃泌素水平进行性升高(P<0.01);由胃糜烂或溃疡至萎缩性胃炎有所下降(P<0.01)。由萎缩性胃炎至不典型增生,血清胃泌素水平明显升高(P<0.01)。由不典型增生至胃癌,血清胃泌素水平明显降低(P<0.01)。胃癌的血清胃泌素水平显著低于其他胃疾病组(P<0.01)。结论:高原地区由于低氧环境引起机体的低氧血症,使胃黏膜表面出现点状出血、水肿、瘀血,血流缓慢,黏液分泌功能降低,胃肠功能屏障受损,加之红细胞增多,血液黏稠,毛细血管瘀血,血栓形成,引起胃黏膜糜烂、溃疡、坏死。60岁以后老年人的胃泌素水平已开始倾向升高,所以血清胃泌素是鉴别良恶性疾病的一个较好的标志物。更多还原

【Abstract】 Objective: To observe the changes of level of grastrin to determine the impact factors and diagnostic value of gastrin in gastric cancer in Xining area.Methods: 781 serum samples source from admitted patients in our hospital coving the period of Jan.2006 and June 2009 were collected and the levels of serum gastrin were measured by enzyme-linked immunosorbent assay(ELISA).The data were analyzed calculatedly by SPSS 11.5 software.Results: As compared with the control group,respectively,the level of serum gastrin was higher in ≥60 years old group,patients with gastric antral disease and positive helicovacter pyloron(HP) group(P <0.01).The transition to a superficial gastritis to gastric erosions or ulcers,as well as atrophic gastritis to dysplasiathe,level of serum gastrin increased(P <0.01);by way of contrast,gastric erosions or ulcers to atrophic gastritis.Other than,level of serum gastrin was lower in gastric cancer group than that in other control groups(P <0.01).Conclusions: There is a tendency of increased serum gastrin level in age person over 60 years,and the level of serum gastrin is a good marker in differential diagnosis of benign or malignant gastric diseases.更多还原