【摘要】 目的探讨P504S、EZH2和pim-1在前列腺癌组织中的表达和意义。方法采用免疫组织化学技术检测P504S、EZH2和pim-1在前列腺癌和前列腺增生中的表达,分析其表达水平与Gleason评分的关系。结果 P504S、EZH2和pim-1在前列腺癌中均为明显高表达,其与Gleason评分的相关性分别为0.418(P<0.05)、0.268(P>0.05)和0.567(Ρ<0.01)。结论 P504S、EZH2和pim-1对前列腺癌均具有高度敏感性和特异性,其表达强度与Gleason评分存在一定的相关性,对前列腺癌的预后判断有参考价值。更多还原

【Abstract】 Objective To determine the expression of P504S,EZH2 and pim-1 in prostate cancer and its correlation with Gleason score.Methods Immunohistochemical stain was used to study the expression of P504S,EZH2 and pim-1 in prostate cancer and benign prostate hyperplasia.Its expression level was analysed with respect to Gleason score.Results P504S,EZH2 and pim-1 was overexpressed in prostate cancer.And Gleason score was positively correlated with P504S(0.418,Ρ<0.05),EZH2(0.268,Ρ<0.05)and pim-1(0.567,Ρ<0.01).Conclusions P504S,EZH2 and pim-1 are sensitive and specific marker for prostate cancer.The expression level of P504S,EZH2 and pim-1 was related to Gleason score.更多还原