【摘要】 目的 :探讨醒脑静注射液对新生大鼠缺氧缺血性脑损伤的影响。方法:将新生7日龄SD大鼠108只随机分为假手术组、缺氧缺血组、醒脑静干预组。观察醒脑静注射液对缺氧缺血72小时后脑组织含水量以及24小时、48小时和72小时后实验侧脑组织匀浆MDA和S0D含量的影响。结果 :与假手术组比较,缺氧缺血组大鼠脑组织含水量、脑组织MDA含量明显增高,SOD含量显著降低。与缺氧缺血组比较,醒脑静干预组大鼠脑组织含水量、脑组织MDA含量明显降低,SOD含量显著增高。结论 :醒脑静注射液对新生大鼠缺氧缺血性脑损伤有保护作用,可以减轻脑水肿,抑制自由基的生成。更多还原

【Abstract】 Objective:To explore the neuroprotective effects of xingnaojing injection on neonatal rats after hypoxic-ischemic brain damage.Methods:108 seven-day-old postnatal rats were distributed randomly into sham operation group,hypoxic-ischemic group and xingnaojing injection therapy group.The levels of water contents,MDA and SOD in brain homogenate were measured after animals were sacrificed at set time.Results:Compared with sham operation group,the level of water contents and MDA in hypoxic-ischemic group was increased significantly,but the content of SOD was decreased sharply.The level of water contents and MDA was declined considerably in xingnaojing injection therapy group compared to hypoxic-ischemic group,but the content of SOD was enhanced dramatically.Conclusion:Xingnaojing injection could protect the brain of neonatal rats after hypoxic-ischemic brain damage,relieve the cerebral edema and inhibit the free-radical production.更多还原