【摘要】 改进了除草剂唑草酮的合成工艺,以4-氯-2-氟苯肼为原料,经氨基腙合成、光气环合制成取代芳基三唑啉酮,再经二氟甲基化、硝化、加氢还原合成中间体1-(5-氨基-4-氯-2-氟苯基)-3-甲基-4-二氟甲基-1H-1,2,4-三唑啉-5-酮,重氮化后与丙烯酸乙酯反应,经后处理得唑草酮。更多还原

【Abstract】 The synthesis process of carfentrazone-ethyl was greatly improved.Using 4-chloro-2-fluorophenylhydrazine as the raw material,substitutional aryl-triazolinones was prepared by synthesis of amidrazone and phosgene cyclization.Then intermediate product 1-(5-amino-4-chloro-2-fluorophenyl)-3-methyl-4-difluoromethyl-1H-1,2,4-triazole-5-one was got through difluoromethylation and nitration and hydrogenating reduction.By means of the process of diazotization and then reacting with ethyl acrylate,carfentrazone-ethyl was finally obtained.更多还原