【摘要】 为了指导己唑醇微乳剂的开发,在已确定己唑醇微乳剂配方的基础上,通过改变配方组份及用量,研究了溶剂、表面活性剂和无机盐等对微乳剂低温贮存稳定性的影响。结果表明:当溶剂用量相同,溶剂体系极性减弱时,微乳剂低温稳定时间延长,反之则缩短;在溶剂极性适当的条件下,溶剂的用量与微乳剂低温贮存稳定时间成正相关;同类型表面活性剂,当HLB值降低、表面活性剂用量提高时,微乳剂低温贮存稳定性提高;碳链长度小于5个碳的醇会缩短制剂的低温贮存稳定时间,并与用量成负相关;碳链长度大于5个碳的醇则会增加制剂的低温贮存稳定时间,且与用量成正相关;添加无机盐类则对制剂的低温贮存稳定性起破坏作用。更多还原

【Abstract】 In order to optimize the formula of hexaconazole microemulsion,the storage stability of hexaconazole ME at low temperature was studied by altering the components and dosage of solvents,surfactants and salts in the basic formula.The results showed that the stable period of ME was prolonged when the polarity of solvent system decreased,and the period was shortened when the polarity increased.When the polarity of solvent system was suitable,the stable period of of ME at low temperature would prolong as the dosage of hexaconazole increased.The storage stability of hexaconazole ME at low temperature was also affected by the type and content of surfactants.Among the same type of surfactants,as the HLB value decreased,the storage stability at low temperature increased.Alcohol compounds had significant impact on the storage stability of hexaconazole ME at low temperature.When the number of carbon in the compounds was less than 5,the stable period was shortened;when the number was equal to or more than 5,the stable period became longer.Addition of inorganic salts damaged the storage stability of hexaconazole ME at low temperature.更多还原