【摘要】 目的探讨男性不育症中少精子症、严重少、弱、畸精子症和无精子症与染色体异常的关系。方法采用外周血淋巴细胞培养,常规制备染色体,应用G显带技术进行核型分析。结果在精液分析异常的567例患者中共发现1 01例染色体异常,异常率为1 7.8%(1 01/567)。在少精子症、严重少、弱、畸精子症和无精子症患者中异常染色体检出率分别为6.8%(6/88)、1 5.4%(2/1 3)、14.3%(3/21)、0%(0/1)和20.3%(90/444)。还发现各种类型的染色体多态51例,发生率为9.0%(51/567)。结论染色体的异常是精子发生障碍的原因之一,染色体检查对精液分析异常患者的诊断与治疗有重要意义。更多还原

【Abstract】 Objective To investigate the relationship between chromosomal abnormalities and oligozoospermia, severe oligozoospermia, asthenozoospermia, teratozoospermia as well as azoospermia. Methods Chromosome specimens were made from peripheral blood lymphocytes. Karyotyping analysis was conducted by G banding. Results Of 567 patients with abnormal semen, 101 cases(17.8%,101/567) were detected to have abnormal chromosomes. And the rates of abnormal chromosome was 6.8% (6/88), 15.4% (2/13), 14.3% (3/21), 0%(0/1) and 20.3%(90/444) respectively in patients with oligozoospermia, severe oligozoospermia, asthenozoospermia, teratozoospermia and azoospermia. And 51 cases with polymorphic chromosomes (9.0%) were observed in 567 patients. Conclusion Chromosomal abnormalities might be the major factor for spermatogenic arrest. Chromosome screening test was very important for diagnosis and treatment of patients with abnormal semen.更多还原