【摘要】 目的探讨染色体检查在精子库筛选供精者中的作用,为预防供精人工受精后染色体病患儿的出生提供依据。方法采用外周血淋巴细胞培养,常规制备染色体,应用G显带技术进行核型分析。结果 750例精液初筛合格的供精者染色体中,发现5例异常,发生率为0.666%。还发现各种类型的染色体多态55例,发生率为7.334%。结论供精者即使精液初筛合格,经过染色体检查也能发现染色体异常患者,这对预防供精人工受精后染色体病患儿的出生有着重要意义。更多还原

【Abstract】 Objective To investigate the effect of chromosomal analysis on sperm bank screening for preventing born baby with chromosomal abnormality after artificial insemination. Methods Chromosome specimens were made using routine culture of peripheral blood lymphocytes. Karyotyping was analyzed by G banding stains. Results Five cases with abnormal chromosomes (0. 67% ) were detected in 750 donors with qualified semen after primary screening test Polymorphism was found in 55 cases and the polymorphism rate was 7.33%. Conclusion Abnormal chromosomes can be found in eligible donors who passed the primary semen screening test. Chromosome analysis was of great significance in preventing birth defects after artificial insemination.更多还原