【摘要】 目的:研究LCH形态结构特征、免疫表型、临床表现。方法:应用HE染色和免疫组化SP法标记CD1a和S-100阳性以确定诊断。结果:15例LCH有4种组合类型:①肾形及卵圆形细胞5例;②咖啡豆样细胞4例;③咖啡豆样及大圆形细胞4例;④大圆形细胞2例。结论:咖啡豆样细胞是LCH的特征细胞,具有重要诊断价值,嗜酸性粒细胞是LCH重要的组成成分之一。根据细胞形态、分化程度和不同组合,LCH分为:①反应性,②交界性,③低度恶性,④高度恶性(肉瘤型)。更多还原

【Abstract】 Objective:To study the morphologic characteristics,immunoexpressive types and the clinical features.Methods: Routine histopathology techniques,immunohistochemistry(SP method) of CD1a and S-100 were used to make the diagnosis results.Results: There were four cell types in the fifteen cases of the LCH:①Five cases of oval cell type,②Four cases of "coffee bean" nuclei cells.③Four cases of "coffee bean" and large round cell types④Two cases of large round cells.Conclusions: The coffeebeancells are the characteristic and diagnostic cells for LCH.According to the cell morphology,different-tiation,and the above cell types,the LCH could be divided into:①Reactive,②Borderline,③Lowgrade malignancy,④High grade malignancy(sarcomatous).更多还原