【摘要】 利用影像技术对帕金森病(Parkinson disease,PD)大鼠模型的脑形态与功能信息进行了系统研究。利用磁共振(Magnetic resonance imaging, MRI)及磁共振血管成像(Magnetic resonance angiography, MRA)获取PD大鼠脑部形态影像资料,利用质子磁共振波谱(1H-magnetic reso-nance spectroscopy,1H-MRS)及CT灌注(CT perfusion,CTP)成像获取波谱及血流变化等功能影像学资料。研究结果表明PD大鼠在形态上影像无特征性异常,在功能影像学纹状体存在局部脑血流降低和波谱变化。更多还原

【Abstract】 Imaging technologies are utilized to study the brain morphology and the functions of rat models of Parkinson disease (PD).Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) are used to obtain morphological imaging data.Functional imaging data,such as the spectrum and blood flow changes are obtained by proton magnetic resonance spectroscopy (1H-MRS) and CT perfusion (CTP).Results show that PD rat models have no characteristic morphological imaging abnormalities,but exist regional cerebral blood flow (CBF) reductions and spectral changes in the striatum.更多还原