【摘要】 目的探讨C-met蛋白表达在甲状腺肿瘤血管生成中的作用及其临床意义。方法采用即用型二步法免疫组化检测53例甲状腺肿瘤组织中C-met和CD34的表达情况。结果甲状腺癌组织中C-met蛋白表达阳性率为92.5%,甲状腺腺瘤C-met蛋白表达阳性率为22.7%,在正常组织中未见阳性表达(P<0.01)。微血管密度在C-met表达阳性者明显高于C-met表达阴性者,两者间差异有显著性意义(P<0.05)。甲状腺癌的微血管密度值与组织类型、分化程度、淋巴结转移和肿瘤分期有关(P<0.05),而与患者性别、年龄和肿瘤大小无关。结论原癌基因C-met与甲状腺肿瘤的发生发展密切相关,既可以促进肿瘤细胞的增殖,又可以诱导肿瘤细胞血管形成,与甲状腺癌预后不良有重要关系。更多还原

【Abstract】 Objective To study the role of oncogene C-met in the process of tumor angiogenesis of thyroid neoplasm and their clinical significance.Methods Immunochemical technique was used to examine C-met and CD34 expression in 53 cases of thyroid neoplasm tissues.Results The positive expression of C-met oncogene protein in thyroid carcinoma was 92.5%,while it was 22.7%in thyroid adenoma,and it was negative in normal thyroid tissue(P<0.01).Microvessel density was significantly higher in C-met positive group than in C-met negative group(P<0.05). The microvessel density value of thyroid carcinoma significantly correlated with histologic classification, differentiation degree,lymph node metastasis and the stage of the tumor(P<0.05)and it did not correlate with gender,age and size of tumor.Conclusion Oncogene C-met may be involved in the genesis and development of endometrial adenocarcinoma.It may prompt cellular proliferation and induce tumor angiogenesis and correlate with poor prognosis.更多还原