【摘要】 目的建立用于测定坎地沙坦西酯含量的HPLC法。方法采用DIKMA C₁₈（200 mm×4.6 mm,5μm）色谱柱;流动相:10 mmol·L^-1磷酸二氢钾（pH 2.5）-乙腈（35:65,V/V）;流速1.2 mL·min^-1;检测波长254 nm。结果坎地沙坦西酯质量浓度的线性范围为1～200mg·L^-1（r=0.999 9）,平均回收率100.03%,精密度RSD<1.0%,3批样品的含量分别为100.71%、101.27%、101.81%。结论本方法操作简便、快捷,结果准确、可靠,可用于坎地沙坦西酯片的质量控制。更多还原

【Abstract】 AIM To establish a method for the determination of the content of candesartan cilexetil in candesartan cilexetil tablets by HPLC.METHODS A DIKMA C₁₈（200 mm x 4.6 mm,50μm） column was used.The mobile phase was 10 mmol·L^-1 potassium dihydrogen phosphate（pH 2.5） - acetonitrile（35:65,V/V）.The flow rate was 1.2 mL·min^-1 and the detection wavelength was 254 nm.RESULTS The HPLC standard curve was linear within the concentration range of 1 - 200 mg·L^-1（r = 0.999 9）.A mean recovery of candesartan cilexetil was 100.03%with the RSD less than 1.0%.The contents of candesartan cilexetil in the tablets were 100.71%,101.27%and 101.81%respectively in three batches compared to labeled contents.CONCLUSION The quality control method of candesartan cilexetil is accurate and stable.It can be used for the quality appraisal of candesartan cilexetil tablets.更多还原