【摘要】 目的探讨重型宫颈上皮内瘤变(CIN)环状电圈切除(LEEP)术后复发或残留的预测指标。方法对86例伴有高危型HPV感染的CINⅡ～CINⅢ级患者于我院门诊行LEEP术治疗,术后随访2年,再次检测HPV负荷和宫颈细胞,同时行阴道镜检查及宫颈活检术。结果高危型HPV为LEEP术后病变残留或复发的敏感预测指标,其特异度不及宫颈细胞学检查(P<0.05)。结论对于CIN患者LEEP术后的随访,首先检测高危型HPV以确定病变残留或复发的高危人群,同时联合应用细胞学检查以提高预测的特异度。更多还原

【Abstract】 Objective To explore predictors of recurrent or residual for severe cervical intraepithelial neoplasia(CIN)after loop electrosurgical excision procedure(LEEP).Methods Eighty-six outpatients with high-risk human papillomavirus(HR-HPV)infecting CIN Ⅱ~CIN Ⅲ confirmed by histology were treated by LEEP.Follow-up by two years,HR-HPV load was measured.Meanwhile,cervical cytology,colposcopy and cervical biopsy were performed.Results HR-HPV was a sensitive predictor for disease remaining or relapsing after LEEP,but its specificity was not as good as cervical cytology’s(P<0.05).Conclusion During the follow-up after LEEP,we should measure HR-HPV load to identify the high-risk groups for residual or recurrent of the lesions.Meanwhile,cervical cytology should be combined with in order to enhance the specificity of the forecast.更多还原