【摘要】 目的:分析过氧化物酶体增殖因子活化受体(PPAR-γ)的表达与大肠癌临床病理特征之间的关系,并探讨PPAR-γ对大肠癌细胞增殖活性的影响。方法:采用免疫组织化学法,检测56例带有癌旁正常黏膜的大肠癌组织中PPAR-γ与增殖细胞核抗原(PCNA)的表达。结果:PPAR-γ在大肠癌组织中的表达显著高于癌旁正常黏膜组织(P<0.001)。PPAR-γ的表达与肿瘤分化程度、浸润深度、Dukes分期以及淋巴结转移有密切关系(P<0.05)。PPAR-γ的表达程度与PCNA显著相关(P<0.001)。结论:PPAR-γ的表达与大肠癌的分化程度、浸润深度和Dukes分期及淋巴结转移有关;PPAR-γ可促进大肠癌细胞的增殖。更多还原

【Abstract】 Objective:Peroxisome proliferator-activated Receptor γ(PPAR-γ)is a kind of nuclear hormone receptor,which plays important roles in regulating metabolisms. Recently,PPAR-γ was found to express in tumor tissues and cells,which could be activated by its ligands and affect the differentiation,proliferation and apoptosis of tumor cells. The aim of this study is to investigate the relationship between expression of PPAR-γ and pathological characteristics of colorectal cancer,and its effect on proliferation of tumor cells. Methods:Expression of PPAR-γ and PCNA-LI was detected in 56 colorectal cancer tissues by immunohistochemistry. Results:Expression of PPAR-γin colorectal cancer tissues was significantly higher than that in non-cancerous colorectal tissues (P<0.001). Expression of PPAR-γ was closely related to cell differentiation,invasive depth ,lymph node metastasis and Dukes stages of colorectal cancer (P<0.05). Expression of PPAR-γ was closely associated with PCNA (P<0.001).Conclusions:Expression of PPAR-γ was relates to colorectal cancer differentiation ,invasive depth ,lymph node metastasis and Dukes stages. Expression of PPAR-γ was closely associated with PCNA. PPAR-γ may be a new target for diagnosis and treatment of colorectal cancer in the future.更多还原