【摘要】 目的:诊断一种伴有血栓性血小板减少性紫癜(TTP)特征的感染性弥散性血管内凝血(DIC),确定其临床与实验室检查的特点。方法:观察患者的临床经过,常规方法做血液生化与凝血检测以及血液细菌培养,用残余胶原结合实验测定血浆ADAMTS13活性及其抑制物。结果:患者有严重感染/败血症,临床呈暴发性经过,且有多器官功能衰竭。实验室检测显示消耗性凝血障碍,ADAMTS13活性明显降低,并存在ADAMTS13抑制物。结论:感染性DIC伴有TTP特征可能是一种新的综合征,临床呈暴发性经过,多器官功能衰竭是其死亡的主要原因。更多还原

【Abstract】 Objective:To diagnose two cases of sepsis-induced disseminated intravascular coagulation (DIC) with features of thrombotic thrombocytopenic purpura (TTP) and to identify its clinical and laboratory characteristics.Method:Clinical course of the two patients was observed. Blood biochemistry,coagulation tests,and blood bacteria culture were performed. ADAMTS13 activity and its inhibitor were analyzed by using collagen binding assay for ADAMTS13.Result:The patients had severe infection/sepsis,and been demonstrated fatal fulminant process of multiple organ dysfunction. Consumptive coagulopathy was showed in laboratory examination and ADAMTS13 deficiency was doseved for ADAMTS13 inhibitor.Conclusion:Patients suffering from sepsis-induced DIC with features of TTP might have been a fulminant course and fatal outcome,which represent a new specific syndrome. Multiple organ dysfunction is the major cause of death.更多还原