【摘要】 目的:研究河北地区汉族人β2肾上腺素受体(β2-Adrenergic Receptor,β2-AR)Arg16Gly基因多态性与原发性高血压(EH)的关系。方法:选择514例EH患者及550例正常人,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析β2-ARArg16Gly基因型。结果:EH组β2-ARArg16Arg,Arg16Gly,Gly16Gly基因型频率分别为21.3%、54.8%和23.9%,正常对照组分别为28.2%、68.2%和3.6%,2组间3种基因型频率差异有统计学意义(P<0.05)。EH组β2-ARArg16等位基因频率为51.8%,Gly16等位基因频率为48.2%;正常对照组分别为63.9%和36.1%,2组间等位基因频率比较,差异有统计学意义(P<0.05)。结论:β2-ARArg16Gly多态性Gly等位基因可能是EH的遗传易感基因。更多还原

【Abstract】 Objective:To study the relationship between polymorphism of β2-adrenoceptor (β2-AR) gene at locus 16 (Arg/Gly) and essential hypertension (EH).Method:514 hypertensives and 550 normotensives were involved.β2-AR genotypes were determined,by polymerase chain reaction (PCR-RFLP).Result:The observed genotype frequencies in the EH and control groups were in Hardy-Weinberg equation (P>0.05).The frequencies of three genotypes (Arg/Arg,Arg/Gly and Gly/Gly) were21.3%,54.8% and 23.9% in hypertensives and 28.2%,68.2% and 3.6% in controls respectively.The distributions of the genotypes were significantly different between two groups (P<0.05).The frequencies of Arg and Gly allele in hypertensives were 51.8% and 48.2% respectively;in controls were 63.9% and 36.1% respectively.The allele frequencies were significantly different between two groups (P<0.05).Conclusion:β2-AR Arg16Gly gene polymorphism was possibly associated with EH in this study population.更多还原