【摘要】 目的:评价中国农村地区未经抗癫癎药物(AEDs)治疗的全身强直-阵挛发作(GTCS)癫癎患者的认知功能的状况。方法:采用数字广度测验、言语流畅性测验、听觉词语测验及数字划消测验对144例GTCS患者和144名健康对照者进行认知功能评定。结果:GTCS患者的注意力及计算能力较差,并有瞬间语言记忆、自发的语言运动能力、思维组织能力及干扰抑制能力的下降。结论:未经AEDs治疗的GTCS患者存在广泛的认知功能障碍。AEDs的非规范使用是认知功能损害的主要影响因素。更多还原

【Abstract】 Aim:To evaluate the cognitive function in untreated patients with generalized tonic-clonic seizure (GTCS).Methods:144 patients with GTCS and 144 normal controls were evaluated with a battery of neuropsychologic tests,which comprises Digit Span Test,Verbal Fluency Test,Auditory Verbal Learning Test and Digit Cancellation Test.Results:Patients with GTCS performed worse of general cognitive deficits,such as verbal memory,episodic memory,verbal learning capacity,visual spatial memory,attention,and calculative ability.Conclusion:The cognitive function of untreated patients with GTCS are widely impaired.Unstandardized treatment with anti-epileptic drug is the main impact factor of cognitive function impairment.更多还原