【摘要】 目的评价小剂量氨溴索对单肺通气(OLV)患者炎性反应的影响。方法剖胸手术OLV患者30例,随机均分为两组:A组于OLV前25min静脉输注氨溴索1mg/kg(生理盐水稀释至100ml,5ml/min),B组静脉输注等容量生理盐水作为对照。于麻醉诱导前(T0)、OLV前即刻(T1)、OLV30min(T2)、1h(T3)、2h(T4)、恢复双肺通气(TLV)1h(T5)、2h(T6)和术后24h(T7)采集桡动脉血样,测定血清肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-8的浓度,并行WBC和中性粒细胞(PMN)计数。结果与B组比较,A组的IL-6在T5～T7时、IL-8在T3～T7时、TNF-α在T4～T7时、WBC计数在T4～T7时、PMN计数在T5～T7时均降低(P<0.05或P<0.01)。结论氨溴索1mg/kg可减轻OLV患者炎性反应。更多还原

【Abstract】 Objective To study the inhibitory effect of ambroxol on perioperative inflammatory responses in patients undergoing one-lung ventilation(OLV).Methods Thirty patients undergoing thoracic surgery and OLV were randomly divided into two groups with 15 cases each. The patients were given OLV during intrathoracic procedure,in group A ambroxol 1 mg/kg in 100 ml of saline was injected in 20 min at 25 min before OLV,while in group B equal volume of injection normal saline was infused as the controls. Blood samples were taken before anesthesia(T0),before OLV(T1),at 30 min(T2),1 h(T3),2 h(T4) during OLV 1 h(T5),2 h(T6)after OLV,and 24 h(T7) after operation for detecting the serum levels of tumor necrosis factor α(TNF-α),interleukin(IL)-6 and IL-8,and accounting WBC and PMN. Results Serum levels of TNF-α at T4-T7,IL-6 at T5-T7,and IL-8 at T3-T7 were significantly lower in group A than those in group B(P<0.05 or P<0.01). So did the counts of WBC at T4-T7 and PMN at T5-T7(P<0.05 or P<0.01).Conclusion Ambroxol 1 mg/kg injected before OLV may attenuate perioperative inflammatory responses in patients undergoing thoracic surgery.更多还原