【摘要】 目的研究应用盐酸戊乙奎醚对慢性阻塞性肺病(chronic obstructive pulmonary dis-ease,COPD)病人气管内插管应用呼吸机后呼吸力学参数的影响。方法COPD病人66例随机均分为两组:盐酸戊乙奎醚组(Ⅰ组):气管插管应用呼吸机前静注盐酸戊乙奎醚1mg;对照组(Ⅱ组):不给予任何支气管扩张药物。分别观察并监测气管内插管应用呼吸机后1、4和6h的呼吸力学参数(气道压力、气道阻力和胸肺顺应性)。结果Ⅰ组各个时间点的气道峰压、气道平台压以及气道阻力明显低于Ⅱ组(P<0.05),而胸肺顺应性明显高于Ⅱ组(P<0.05)。结论盐酸戊乙奎醚可明显降低COPD病人气管内插管后的气道压力和气道阻力,增加胸肺顺应性。更多还原

【Abstract】 Objective To investigate the effects of penehyclidine on respiratory mechanics after tracheal intubation in patients with chronic obstructive pulmonary disease.Methods Sixty-six patients with chronic obstructive pulmonary disease were divided randomely into two groups. Group Ⅰ(penehyclidine group,33 cases) was intravenously injected 1 mg of penehyclidine before intubation,group Ⅱ(control group,33 cases)was not given bronchodilator. Lung-chest wall compliance,airway pressure,and resistance were measured at 1 h,4 h,and 6 h after tracheal intubation.Results Patients in groupⅠ had significantly both lower airway pressure and resistance and higher lung-chest wall compliance than groupⅡ(P<0.05).Conclusion Penehyclidine produces higher lung-chest wall compliance and lower airway pressure and resistance in patients with chronic obstructive pulmonary disease.更多还原