【摘要】 目的:比较布洛芬和独一味对大鼠正畸牙牙根吸收的作用。方法:32只Wistar大鼠建立正畸牙移动根吸收的动物模型,100g初始力值加载于大鼠右侧上颌中切牙与第一磨牙之间,随机分为生理盐水组、布洛芬组、独一味组。应用图像分析系统测量牙根吸收陷窝的数目、长度、深度;应用抗酒石酸酸性磷酸酶(Trap)染色对牙槽骨、牙根表面分区进行破骨细胞计数;扫描电镜观察牙根表面吸收状态。结果:布洛芬和独一味降低了牙根吸收长度指数、吸收陷窝的平均长度和深度,并且减少了破骨细胞的数量,但是二者的作用差别没有显著性。结论:布洛芬和藏药独一味对大鼠正畸性牙根吸收有抑制作用。更多还原

【Abstract】 Objective:To compare the effects that ibuprofen and Chinese herbal medicine Duyiwei have on root resorption associated with orthodontic movement.Method:32 Wistar rats were randomly divided into three experimental groups:control group,ibuprofen group and Duyiwei group.An initiate force of 100 grams was applied beween the left maxillary first molars and the incisors in all the animals.Histological examinations were performed on all above samples.An image analysis system was used to mesure the number,length and depth of the root resorption lacunaes,tartrate-resistant acid phosphatase was used to quantify mature and committed clast cells,scanning electron microscope examinations were used to observe the root resorption area.Result:ibuprofen and Duyiwei significantly decreased root resorption index,the average length and depth of the resorption lacunas and reduced the number of clast cells,however,there was no statistically significant difference between ibuprofen group and Duyiwei group.Conclusion:ibuprofen and Duyiwei may have an inhibitory effect on orthodontically induced root resorption.更多还原