【摘要】 目的:了解急性期精神分裂症患者主观睡眠质量及奎硫平、阿立哌唑对患者主观睡眠质量的影响。方法:将符合国际疾病分类第10版精神分裂症诊断标准的患者68例,按入院的先后顺序分为奎硫平组34例和阿立哌唑组34例,用匹兹堡睡眠质量指数(PSQI)和睡眠状况自评量表(SRSS)进行主观睡眠评价,用阳性和阴性症状量表(PANSS)、简明精神病评定量表(BPRS)评定精神症状。用治疗中出现的症状量表(TESS)评定不良反应。结果:共57例完成研究。奎硫平组治疗前PSQI总分平均(11.81±4.81)分、治疗后(1.14±1.75)分;SRSS总分治疗前(32.16±7.13)分、治疗后(16.10±4.67)分。阿立哌唑组治疗前PSQI总分平均(10.97±5.28)分、治疗后(3.60±3.71)分;SRSS总分治疗前平均(29.73±7.31)分、治疗后(20.33±10.53)分。多元逐步回归分析显示,入组时PSQI总分、SRSS总分与PANSS分呈正相关(r=0.496,P=0.000;r=0.391,P=0.000)。结论:急性期精神分裂症患者主观睡眠质量降低,入睡时间延长,实际睡眠时间减少。经奎硫平或阿立哌唑治疗后,睡眠质量改善。更多还原

【Abstract】 Objective:To study the subjective sleep quality of schizophrenic patients at the acute stage and the effects of quetiapine and aripiprazole on their sleep quality. Method:Sixty-eight patients with schizophrenia meeting the schizophrenia criterion of International Classification of Diseases-10(ICD-10) were enrolled into the study.They were divided into two groups according to the sequence of admission:quetiapine group including 34 cases and aripiprazole group including 34 cases.The positive and negative syndrome scale(PANSS) and brief psychiatric rating scale(BPRS) were used to evaluate the psychopathology.Pittsburg sleep quality index(PSQI) and self-rating scale of sleep(SRSS) were used to estimate subjective sleep quality.Treatment emergent symptom scale(TESS) were used to evaluate the side effects. Results:57 patients finished the experiment.In quetiapine group,the total scores of PSQI and SRSS at pre-treatment were(11.81±4.81)and(32.16±7.13).At the end of week 8 they decreased to(1.14±1.75) and(16.10±4.67).In aripiprazole group the scores of PSQI and SRSS were(10.97±5.28) and(29.73±7.31).At the end of week 8 they decreased to(3.60±3.71) and(20.33±10.53).Stepwise regression analysis indicated the total scores of PSQI and SRSS at pre-treatment were positively correlated with total scores of PANSS(r=0.496,P=0.000;r=0.391,P=0.000). Conclusion:Patients with schizophrenia show decreased subjective sleep quality at the acute stage,prolonged sleep latency,shorted total sleep time.Quetiapine and aripiprazole can improve sleep quality.更多还原