【摘要】 目的观察富露施联合激素、抗生素治疗放射性肺炎的临床疗效。方法将62例患者随机分为单纯激素抗生素组(对照组)30例,富露施联合激素抗生素组(治疗组)32例,两组治疗6周。治疗前、后进行肺炎评级、观察症状疗效及X线胸片疗效,检测治疗前后血清细胞因子白介素-6(IL-6)、转化生长因子-β(TGF-β)水平。结果治疗组治疗后肺炎评级的改善、X线胸片疗效明显优于对照组(P<0.01),血清IL-6、TGF-β水平均明显低于治疗前,与对照组治疗后比较差异有统计学意义(P<0.05)。结论富露施联合激素、抗生素治疗放射性肺炎疗效确切,能有效降低放射性肺炎患者的血清IL-6、TGF-β水平。更多还原

【Abstract】 Objective To observe the clinical therapeutic effect of Fluimucil combined hormones,antibiotic therapy(HAT) on radiation pneumonia(RP).Methods 62 patients with RP were randomly divided into two groups,30 cases in control group and 32 cases in treatment group were treated with HAT alone and HAT combined with Fluimucil for 6 weeks.The severity of RP was evaluated before and after treatment according to the criteria of the radiation therapy oncology group.The effect on symptoms and chest roentgenogram,as well as on plasma levels of interleukin-6(IL-6) and transform growth factor-beta(TGF-beta) were detected.Results After treatment,the pneumonia improved rating,X-ray effect much better than the control group(P < 0.01),serum IL-6,TGF-β were significantly lower than before treatment,after treatment compared with the control group the difference was statistically significant(P < 0.05).Conclusion Fluimucil combined with hormone,antibiotic therapy has exact effect on radiation pneumonia,serum IL-6,TGF-β levels can be reduced effectively in patients with radiation pneumonia.更多还原