【摘要】 目的探讨气道微环境改变对嗜中性粒细胞和嗜酸性粒细胞的影响。方法 1.先用趋化小室的方法,探讨支气管黏液的粘稠度对嗜中性粒细胞趋化专用的影响,2.通过研究诱导痰引起的炎症细胞的改变,探讨气道微环境改变对嗜中性粒细胞和嗜酸性粒细胞的影响。结果 1.黏液干重从1.5%增加至6.5%,粘蛋白的浓度增加了10倍以上,嗜中性粒细胞重力方向和水平方向的趋化能力在1.5%黏液中最强,逆重力方向的趋化能力在2.5%黏液中最强,在6.5%嗜中性粒细胞黏液中,几乎没有趋化运动。2.反复诱导痰在健康人群中不仅可以引起一过性的嗜中性粒细胞增多的反应,而且还引起一个延长的嗜酸性粒细胞增加的炎症反应。结论气道微环境改变对嗜中性粒细胞和嗜酸性粒细胞有影响。更多还原

【Abstract】 Objective To investigate the effects of neutrophil and eosinophil when the airway micro-environment changed.Methods 1.First to explore the viscosity of bronchial mucus of neutrophil-specific chemokine by chemotaxis chamber method 2.To explore the effects of neutrophil and eosinophil when the airway micro-environment changed by studying the induced sputum inflammatory cells.Results It could not only cause a transient increase in neutrophil response,but also cause a prolonged increase in eosinophil airway inflammation in response by repeated induced sputum in healthy people.Conclusion It is influential to neutrophil and eosinophil when the micro-environment changed.更多还原