【摘要】 目的探讨CT引导经皮冷极射频消融联合化放疗治疗老年局部晚期非小细胞肺癌(NSCLC)的疗效。方法回顾性分析2005年12月至2009年3月采用冷极射频消融联合化放疗治疗老年局部晚期非小细胞肺癌30例资料,选择同期条件相同采用常规化放疗治疗局部晚期NSCLC28例作对照;比较两组病人的KPS、局部控制率、局部复发率、生存率。结果治疗组和对照组的KPS改善率分别为53.33%和32.14%,局部控制率分别为73.33%和46.43%;治疗组KPS评分稍优于对照组,但无显著性差异(χ2=2.65,P>0.05)。局部复发率治疗组显著低于对照组(20%v46.43%;χ2=6.18,P<0.05)。中位生存期治疗组16.6个月,对照组14.1个月;1、2年生存率治疗组稍高于常规组(63.53%v53.50%,31.99%v29.13%),但两组间比较无统计学意义(χ2=0.33,P>0.05)。结论射频消融联合化放疗可有效地控制局部病灶的进展,降低不可切除NSCLC的局部复发率,改善病人功能状态。更多还原

【Abstract】 Objective To evaluate the clinical efficacy of CT-guided cool-tip radiofrequency ablation and chemoradiotherapy for the treatment of locally advanced non-small cell lung cancer in elderly.Methods Thirty patients with locally advanced non-small cell lung cancer(the treatment group,group A)were treated by combination of chemoradiotherapy and percutaneous cool-tip radiofrequency ablation from Dec.2005 to May 2003.The efficacy was compared with those of 28 patients who received conventional chemotherapy and/or radiotherapy(the control group,group B)in the same period.Results The treatment group and control group of KPS improvement rates were 53.33% and 32.14%,local control rates were 73.33% and 46.43%;the treatment group KPS was slightly better than the control group,but no significant difference(χ2=2.65,P>0.05).The local recurrence rate of the primary treatment group was significantly lower than the control group (46.43% v 20%;χ2=6.18,P<0.05).The median survival time was 16.6 months in the treatment group,14.1 months in the control group;1,2-year survival rate was slightly higher than the conventional group(63.33% v 53.57%,30% v 17.86%).There was not statistically different in 1,2-year survival rates.Conclusion Combined chemoradiotherapy and percutaneous cool-tip radiofrequency ablation by controllable cool-tip needle can decrease local recurrence and improve performance status for locally advanced non-small cell lung cancer in elderly.更多还原