【摘要】 目的检测急性发作期老年晚发哮喘(LOA)诱导痰细胞学、嗜酸细胞阳离子蛋白(ECP)和白介素-5(IL-5)、白介素-8(IL-8)水平,观察LOA气道炎症特征。方法检测86例急性发作期LOA患者诱导痰中细胞学分类计数、ECP和IL-5、IL-8水平;选择30例健康老年人作为对照。结果以诱导痰中EOS数量≥3%作为临界值,86例急性发作期LOA患者中,79例(81%)诱导痰中嗜酸细胞(EOS)数量增高,为痰EOS增高组;17例(19%)痰中性细胞数量增高,为痰非EOS增高组。痰非EOS增高组诱导痰中性细胞和IL-8水平显著高于痰EOS增高组和健康老年组(P<0.01);而痰中EOS数量、ECP和IL-5水平显著低于痰EOS增高组(P<0.01),但与健康老年组比较差异无统计学意义(P>0.05)。结论急性发作期LOA患者存在气道嗜酸细胞和中性细胞两种炎症类型,测定患者气道炎症类型有助于指导治疗。更多还原

【Abstract】 Objective To examine cell counts,levels of eosinophil cationic protein(ECP),interleukin-5(IL-5)and interleukin-8(IL-8)in induced sputum and to identify the characteristic of airway inflammation in elderly patients with late onset asthma(LOA)during their acute exacerbation period.Methods Cell counts and levels of ECP,IL-5 and IL-8 in induced sputum were measured in 86 elderly patients with LOA during their acute exacerbation period.30 healthy elderly subjects were selected as controls.Results The percentage of neutrophil and level of IL-8 in induced sputum in LOA patients with sputum noneosnophilia during their acute exacerbation period were higher than those in LOA patients with sputum eosinophilia,and higher than those in the healthy elderly subjects(all P<0.01),but their sputum percentage of Eos,levels of ECP and IL-5 were lower than those in the LOA patients with sputum eosinophilia(all P<0.01).Conclusion Induced sputum analysis in LOA patients during their acute exacerbation period can identify airway eosinophil and neutrophil inflammatory patterns.It may be a helpful guidance for the treatment.更多还原