【摘要】 目的:研究舌黏膜鳞状细胞癌(舌癌)中波形蛋白的表达,探讨其在舌癌复发转移中的意义。方法:采用免疫组化方法检测30例舌癌患者组织中波形蛋白的表达,并分析其表达水平与临床病理及预后之间的关系。结果:正常口腔黏膜中不表达波形蛋白。在舌癌病例,约33%(10/30)患者的癌组织中波形蛋白呈高表达;67%(20/30)患者的癌组织中波形蛋白呈阴性或低表达。波形蛋白表达水平与患者的性别、年龄、肿瘤分化程度、临床分期之间无统计学意义;波形蛋白的表达水平与肿瘤大小(P=0.007)、淋巴结转移(P=0.007)及复发(P=0.007)之间在统计学上有显著性差异。结论:舌癌组织中波形蛋白的高表达与肿瘤复发、转移之间密切相关,有可能作为舌癌患者预后的预测指标。更多还原

【Abstract】 Objective:To evaluate vimentin,a mesenchymal cell marker,expression in oral squamous cell carcinoma of tongue,and investigate the potential role of these marker associated with the clinicopathologic features and patient prognosis.Methods:This study combined the quantitative immunohistochemistry analysis of vimentin expression in 30tongue carcinoma patients.The relationship between the expression of vimentin and clinicopathologicical features was analyzed.Results:The increased expression of vimentin was observed in 10of 30(33%)tumours from tongue carcinoma patients.There was a statistically significant differences between the expression levels of vimentin and tumour size(P=0.007),lymph node metastasis(P=0.007),recurrence(P=0.007).There was no correlation between the expression levels of vimentin and sex,age,histological differentiation or clinical stage.Conclusion:Our data demonstrated that increased expression of vimentin was closely associated with recurrence and prognosis in tongue carcinoma patients.The aberrant expression of vimentin might provide a useful prognostic marker in oral squamous cell carcinoma of tongue.更多还原