【摘要】 目的在强镇静、镇痛、机械通气条件下对脓毒血症患者进行液体治疗,评估患者HR、MAP、CVP、CO、SV、SVI、SVV等作为液体反应指标的差异以及各指标基础值之间的相关性.方法选择120例脓毒血症患者,按理想体重给予10 mL/kg、20 mL/kg、30 mL/kg万汶注射液,观察上述各项指标变化.结果每搏量变异度(SVV)预测液体反应具有良好的敏感性和特异性.结论血液动力学参数每搏量变异度可以预测危重患者的液体反应,可以作为指导这些患者液体治疗的一个有用指标.更多还原

【Abstract】 Objective On strong sedation and analgesia,adopting fluid resuscitation for treatment of mechanically ventilated(MV)patients with severe sepsis,to evaluate the differences of heart rate(HR),mean arterial pressure(MAP),central venous pressure(CVP).cardiac output(CO),stroke volume(SV),stroke volume index(SVI),stroke volume variability(SVV)as predictors of fluid responsiveness and the correlation among these basic indicators.Methods We selected 120 patients with severe sepsis.According to ideal weight,Voluven were administered to patients at a dose of 10 mL/kg,20 mL/kg,and 30 mL/kg,respectively.Then we observed the changes in hemodynamic parameters mentioned above at the onset of and after quick fluid therapy.Result A SVV value had the better sensitivity and specificity for prediction of fluid responsiveness.Conclusion Hemodynamic parameter SVV can predict fluid responsiveness in critical care patients during fluid resuscitation,and may serve as a useful index for guiding fluid therapy in these patients.更多还原