【摘要】 通过分别给1月龄和3月龄雌性小鼠连续30d皮下注射不同剂量的胸腺肽,研究胸腺肽对血清中促卵泡激素(FSH)、雌二醇(E2)、促甲状腺激素(TSH)和胰岛素(INS)水平的影响。结果表明,各剂量胸腺肽使1月龄小鼠血清FSH、E2水平显著或极显著降低(P<0.05,P<0.01);TSH水平显著或极显著升高(P<0.05,P<0.01);INS水平降低,其中高剂量组INS水平显著降低(P<0.05)。各剂量胸腺肽使3月龄小鼠血清FSH水平降低,其中高剂量组FSH水平显著降低(P<0.05);TSH水平升高,其中高剂量组TSH水平极显著升高(P<0.01);E2、INS水平降低,但差异不显著。可见,胸腺肽能影响雌性小鼠血清激素水平,从而调节雌性小鼠的内分泌系统。更多还原

【Abstract】 After 30 days’ subcutaneous injection of different doses of thymosin into the female mice of different ages (1 month,3 months),serum hormone levels of Follicle-Stimulating Hormone (FSH),Estradiol-2 (E2),Thyroid-Stimulating Hormone (TSH) and Insulin (INS) were detected to determine the effects of thymosin.The results show that for 1 month mice with different doses of thymosin,FSH and E2 levels are decreased significantly or very significantly (P<0.05,P<0.01),TSH levels are increased significantly or very significantly (P<0.05,P< 0.01),INS levels are decreased,and high dose thymosin makes a significant difference in INS (P<0.05).For 3 month mice with different doses of thymosin,FSH levels are decreased and high dose thymosin makes a very significant difference in FSH (P<0.01),TSH levels are increased and high dose thymosin makes a significant difference in TSH (P<0.05).E2 and INS levels are decreased with no significant difference.It is concluded that thymosion influences female mice’s serum hormone level,which in turn affects its endocrine system.更多还原