【摘要】 目的观察冠心病患者血浆溶血磷脂酸水平与冠状动脉狭窄程度的关系,并探讨溶血磷脂酸与炎症和脂质过氧化反应的关系。方法按照美国心脏病学会/美国心脏协会冠心病处理指南的诊断标准并经冠状动脉造影确诊的85例患者纳入该研究,分为三组:急性心肌梗死组31例,不稳定型心绞痛组30例,稳定型心绞痛组24例;并选择冠状动脉造影正常的20例非冠心病患者作为对照组。测定入选者溶血磷脂酸、C反应蛋白和低密度脂蛋白胆固醇水平,并行冠状动脉造影,按照Jenkins评分系统进行评分。比较各组溶血磷脂酸水平,并对溶血磷脂酸与Jenkins评分、高敏C反应蛋白、低密度脂蛋白胆固醇进行Spearman直线相关分析。结果急性心肌梗死组、不稳定型心绞痛组和稳定型心绞痛组溶血磷脂酸水平(分别为4.85±0.36μmol/L、3.67±0.84μmol/L和3.11±0.76μmol/L)明显高于对照组(2.15±0.57μmol/L),急性心肌梗死组溶血磷脂酸水平明显高于不稳定型心绞痛组和稳定型心绞痛组,不稳定型心绞痛组溶血磷脂酸水平明显高于稳定型心绞痛组(P均<0.01)。冠心病患者溶血磷脂酸的表达水平与Jenkins评分(r=0.901,P<0.01)、高敏C反应蛋白(r=0.755,P<0.01)和低密度脂蛋白胆固醇(r=0.549,P<0.01)水平呈正相关。结论冠心病患者血浆溶血磷脂酸水平明显升高,溶血磷脂酸水平可反映冠状动脉的狭窄程度,溶血磷脂酸可能与炎症和脂质过氧化反应有关。更多还原

【Abstract】 Aim To investigate the association between plasma lysophosphatidic(LPA) and coronary stenosis with coronary heart disease(CHD) as well as the roles of LPA in inflammation and lipidperoxidation. Methods Eighty-five patients were diagnosed as CHD according to the results of coronary angiography and ACC/AHA diagnostic criteria.The patients were divided into 3 groups: acute myocardial infarction(AMI) group(n=31),unstable angina(UA) group(n=30),stable angina(SA) group(n=24).Another 20 patients with normal coronary artery served as control.All patients underwent coronary angiography and the results were further evaluated by Jenkins score.The levels of plasma LPA and serum high sensitivity C-reactive protein(hs-CRP) and low density lipoprotein cholesterol(LDLC) were measured. Results The levels of LPA in AMI,UA and SA(4.85±0.36 μmol/L,3.67±0.84 μmol/L and 3.11±0.76 μmol/L) were significantly higher than that in the control group(2.15±0.57 μmol/L),the levels of LPA in AMI group were significantly higher than that in UA and SA,the levels of LPA in UA were significantly higher than that in the SA group(P<0.01).The levels of plasma LPA were positively correlated with Jenkins score(r=0.901,P<0.01),hs-CRP(r=0.755,P<0.01) and LDLC(r=0.549,P<0.01). Conclusion The levels of plasma LPA increased significantly in CHD patients and was positively related with coronary stenosis and serum hs-CRP and LDLC.更多还原