【摘要】 目的动态监测铜绿假单胞菌亚胺硫霉素耐药及泛耐药的变迁,分析探讨耐药性变化的规律和原因,指导临床合理用药。方法回顾性统计分析2006～2008年医院感染病例检出的铜绿假单胞菌的科室分布、标本分布及耐药率等。结果 2006～2008年亚胺硫霉素耐药菌株检出率分别是6.3%、20.93%和38.04%,泛耐药菌株检出率分别是0.45%、0.46%和4.35%。2006～2008年亚胺硫霉素耐药菌株对其他14种常用抗菌药的耐药性明显增加。统计数据显示2008年除丁胺卡那霉素(耐药率21.43%)外,其余药物的耐药率都高达60%以上。亚胺硫霉素耐药菌株主要分布在重症和老年慢性病区。结论顺德市第一人民医院2006～2008年度临床分离的铜绿假单胞菌亚胺硫霉素耐药率和泛耐药率均呈明显上升趋势,泛耐药菌株的快速增加是临床不容忽视的严峻问题。亚胺硫霉素耐药菌株对丁胺卡那霉素具有较高的敏感性。更多还原

【Abstract】 Objective To investigate the clinical distribution,risk fators and antimicrobial resistance of Pseudomonas(P.)aeruginosa to imipenem and its pan-drug resistance for rational use of antimicrobials.Methods The susceptibility test results of P.asaeruginosa isolated from 2006-2008 were analyzed retrospectively.Results The resistance rates of P.aeruginosa to imipenem were 6.3%,20.93% and 38.04% respectively,pan-drug resistance were 0.45%,0.46% and 4.35% respectively in 2006-2008.During these years,imipenem-resistant P.aeruginosa had the increased resistance to other 14 kinds of common used antibiotics.In 2008,except amikacin(the drug-resistance rate 21.43%),the resistance rate of the other drugs reached up to over 60%.P.aeruginosa resistant to imipenem mainly distributed in ICU and and gerontologic department.Conclusion The resistance rates to imipenem and pan-resistance were increased obviously in our hospital during 2006-2008.Doctors should pay more attention to analyze the bacterial resistance profile.Amikacin is the most active agents against the P.aeruginosa isolates更多还原