【摘要】 目的分析不同程度脑白质疏松患者临床特征及影像改变,探讨引起严重脑白质疏松的相关因素。方法 86例脑白质疏松患者按照脑磁共振(MR I)上白质疏松程度分为轻度和重度两组,比较两组患者的临床特征、脑MR I改变。结果高血压、高龄和糖尿病是两组患者的共同危险因素;但轻度白质疏松组与高龄关系比重度组更密切(P=0.018);而重度白质疏松组与高血压关系更密切(P=0.007);重度组患者合并腔隙性脑梗死及轻度认知功能损害的比例明显高于轻度组(P分别为0.001;0.017)。结论高血压是引起重度脑白质疏松的主要危险因素;重度白质疏松多合并腔隙性脑梗死及与轻度认知功能障碍有关。更多还原

【Abstract】 Objective To analyze the clinical characteristics and imaging findings in patients with different rating leukoaraiqsis and to investigate the risk factors of serious leukoaraiqsis.Methods The clinical characteristics and brain magnetic resonance imaging(MRI) findings were obtained in 86 patients with leukoaraiqsis.According to the different rating leukoaraiqsis,patients were divided into two groups,i.e.moderate group and serious group.Their clinical characteristics and MRI findings were compared.Hypertension,age and diabetes were common factors related to leukoaraiqsis.But age was the more obviously factor in moderate leukoaraiqsis than in serious leukoaraiqsis(P=0.018).Results Compared with moderate leukoaraiqsis,hypertension was the main risk factor resulting in serious leukoaraiqsis(P=0.007).The ratios of lacunae infarction and mild cognitive impairment were higher in the serious group than in the moderate leukoaraiqsis group(P=0.001,P=0.017).Conclusion Hypertension is the main risk factor resulting in serious leukoaraiqsis.There is a relationship between serious leukoaraiqsis and lacunae infarction or mild cognitive impairment.更多还原