Objective To observe the expression of CD3+CD56+ NKT-like cells in patients with acute leukemia(AL)before and after treatment in vivo.Methods The bone marrow was collected and examined from 60 AL patients(43 cases of acute myelogenous leukemia,AML;12 cases of acute lymphoblastic leukemia,ALL;5 cases of mixed acute leukemia)and 10 cases of non-tumor control group.The results of the examination with CD3+CD56+ by flow cytometer were compared with above groups.Results Expression of CD3+CD56+ from bone marrow ce...
【基金】
国家自然科学基金(30960139);
江西省教育厅科技计划(赣教技字[2006]75号)
【更新日期】
2010-06-29
【分类号】
R733.71
【正文快照】
自然杀伤性T细胞(natural killer T cells,NKT细胞)作为一种T细胞亚群,是一类新型的免疫调节细胞,它区别于自然杀伤细胞(NK)细胞,以及传统的T、B细胞,既表达T细胞受体TCRαβ(小鼠为Vα14Vβ8,人类为Vα24Vβ11),又表达NK细胞受体[1]。NKT细胞主要特征为T细胞受体(TCR)基因表达