【摘要】 目的比较喹硫平单药和帕罗西汀单药治疗广泛性焦虑的疗效及安全性。方法将110例广泛性焦虑障碍患者随机分为喹硫平200mg/d治疗或帕罗西汀20mg/d治疗。疗程6周。用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表严重度(CGI-SI)评定疗效,用副反应量表(TESS)、实验室检查及体重评定安全性。结果喹硫平组55例患者中有51例完成研究,帕罗西汀组55例中53例完成研究。喹硫平组有效率为74.5%,痊愈率为27.3%;帕罗西汀组分别为81.8%、50.9%。两组有效率差异无统计学意义,喹硫平组痊愈率高(χ2=6.45,P=0.01)。两组HAMA、CGI-SI评分在治疗后均下降;喹硫平组第1周末HAMA总分低于帕罗西汀组;除第1周外,帕罗西汀组量表评分均优于喹硫平组。两组均未发生严重不良事件。喹硫平组嗜睡多见,帕罗西汀组出汗及激越多见;研究结束时,喹硫平组体重增加值高于帕罗西汀组[喹硫平组(M,QR)为1kg(0kg,1kg),帕罗西汀组为0kg(0kg,1kg);Z=4.0,P=0.01]。结论喹硫平短期控制广泛性焦虑障碍的症状比帕罗西汀快,但是帕罗西汀6周总体的疗效优于喹硫平。更多还原

【Abstract】 Objective:Compare the efficacy and safety of quetiapine mono-therapy and paroxetine mono-therapy in generalized anxiety disorder.Methods:Patients with generalized anxiety disorder were randomly assigned to mono-therapy quetiapine 200mg/d or mono-therapy paroxetine 20 mg/d and treated for 6 weeks.Efficacy was assessed with the Hamilton rating scale for anxiety(HAMA)and the severity index of the Clinical Global Impression scale(CGI-SI).Changes in weight,laboratory tests and the results of the Treatment Emergent Symptom Scale(TESS)were used to assess safety.Results:Fifty-one of the 55 subjects in the quetiapine group and 53 of the 55 subjects in the paroxetine group completed the 6 weeks of treatment.No severe adverse events occurred in either group.At the end of treatment the mean scores of HAMA and CGI-SI had dropped significantly in both groups;the efficacy rates for quetiapine and paroxetine were 74.5% and 81.8%,respectively(P>0.05);and the remission rates were 27.3% and 50.9%,respectively(χ2=6.45,P=0.01).At the end of the first week the mean total HAMA score in the quetiapine group was significantly lower than in the paroxetine group,but in all subsequent weeks the score was significantly lower in the paroxetine group.Dizziness was a more common side effect in the quetiapine group while sweating and agitation were more common in the paroxetine group.At the end of the study,the median(interquartile range)weight increase in the quetiapine group was higher than that in the paroxetine group [1kg(0kg,1kg)versus 0kg(0kg,1kg),respectively;Z=4.0,P=0.01)].Conclusion:Quetiapine has a more rapid effect on controlling the symptoms of generalized anxiety than paroxetine,but the overall efficacy of paroxetine over a 6-week course of treatment is superior to that of quetiapine.更多还原