【摘要】 目的探讨急性心肌梗死(AMI)患者急症冠状动脉介入治疗(PCI)不同时间应用替罗非班对于术后CRP水平和预后的影响。方法选择急症入院的84例AMI患者随机分为早期治疗组(n=45)与晚期治疗组(n=39),早期治疗组于急症入院即刻静脉给予替罗非班;晚期治疗组于冠状动脉造影后静脉给予替罗非班。比较两组患者PCI术前、术后的TIMI血流分级;测定PCI术前、术后3dCRP水平;记录住院期间及随访3个月时的主要心血管事件(MACE)的发生率。结果早期治疗组术前TIMI前向血流达到3级的比率明显高于晚期治疗组,而术后无差异;早期治疗组术后3d的CRP水平明显低于晚期组;两组术后住院期间MACE事件有明显差异,而随访3个月期间则无差异。结论AMI患者入院时尽早应用替罗非班对急症PCI治疗是安全有效的,且能够明显改善靶血管前向血流TIMl分级,降低CRP水平,减少住院期间心血管事件。更多还原

【Abstract】 Objective To evaluate the effect of Tirofiban on CRP levels in patients with acute myocardial infarction(AMI) after primary emergency percutaneous coronary intervention(PCI).Methods Eighty-four AMI patients admitted on emergency were randomly divided into two groups:(1) early-treated group(n = 45), immediately receiving Tirofiban intravenously on admission and(2) late-treated group(n = 39), receiving Tirofiban intravenously after coronary angiography was performed.TIMI grading before and after PCI in both groups were compared, CRP levels before and three days after PCI were estimated.The major adverse cardiovascular events(MACEs) occurred during hospitalization and following-up period of three months were recorded.Results Before PCI, TIMI grade 3 forward flow rate in early-treated group was significantly higher than that in late-treated group, while no significant difference existed between two groups after PCI.Three days after PCI, CRP level in early-treated group was markedly lower than that in late-treated group.During hospitalization, the occurrence of MACEs in early-treated group was lower than that in latetreated group, while no marked difference was found between two groups during the following-up period of three months.Conclusion In treating AMI patients with primary PCI, Tirofiban should be used as early as possible, which is safe and effective for PCI and can also significantly improve forward blood flow in target vessels, decrease the CRP level and reduce the occurrence of MACEs during hospitalization.更多还原