【摘要】 目的探讨细胞代谢解毒酶细胞色素P450酶1A1(CYP1A1)、谷胱甘肽S-转硫酶M1(GSTM1)基因多态性和吸烟因素对男性肺鳞癌发病的影响。方法采用基因芯片技术对125例男性肺鳞癌患者和125例男性健康对照者CYP1A1、GSTM1基因多态性进行检测。结果 CYP1A1m2位点GG基因型和GSTM1缺失基因型在肺鳞癌组与健康对照者间存在显著性差异(P<0.05)。吸烟者携带CYP1A1m2位点至少一个变异G等位基因或携带GSTM1缺失型者患肺鳞癌的危险性进一步显著增加,OR值分别为4.50和3.81(P<0.01)。结论吸烟与CYP1A1、GSTM1基因多态性与男性肺鳞癌的发生有关。更多还原

【Abstract】 Objective To explore the effect of cytochrome P450 enzyme 1A1(CYP1A1) and glutathione-S-transferase M1(GSTM1) genetic polymorphism and smoking factor on the occurrence of male lung squamous carcinoma.Methods CYP1A1 and GSTM1 genotypes were detected with oligonucleotidechip technique in 125 male lung squamous carcinoma patients and 125 healthy controls.Results Frequencies of GG genotype at CYP1A1 m2 site and frequencies of GSTM1 null genotypes were significantly increased in lung cancer group compared to control group(P<0.05).When stratified by smoking status,there were increased risk for smokers in lung cancer cases carrying at least one G allele of CYP1A1 m2 site or GSTM1 null genotype,the odds ratios were 4.50 or 3.18 respectively(P<0.01).Conclusion CYP1A1 and GSTM1 gene polymorphism were associated with the occurrence of male lung squamous cell carcinoma,smoking factors and CYP1A1 and GSTM1 polymorphism have a synergistic effect.更多还原