【摘要】 本文通过制备纳米金-多壁碳纳米管复合物(Au-MCNT)修饰玻碳电极,建立了抗癌药物柔红霉素(DNR)作用癌细胞的高灵敏检测方法,研究并追踪了DNR与癌细胞相互作用过程中细胞对DNR的电化学实时响应.结果表明,Au-MCNT修饰电极能实现抗癌药物DNR作用癌细胞的高灵敏实时检测.基于该纳米复合材料的电化学药物传感分析方法可作为抗癌研究中一种方便、快捷、灵敏的实时检测手段,在生物医学等领域具有良好的应用前景.更多还原

【Abstract】 In this paper,we utilized the nanocomposites of gold nanoparticles-multiwalled nanotubes(Au-MCNT) modified glass carbon electrode(GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin(DNR) and cancer cells.Electrochemical analysis indicated that Au-MCNT modified GCE shows high sensitivity and could track the real time responses of cancer cells under DNR treatments.Therefore,this new nano-interface and Au-MCNT modified electrode can be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedicine applications.更多还原