【摘要】 目的了解丙型肝炎病毒(HCV)F抗体在南京市吸毒人群HCV感染者中的分布特点,为丙型肝炎防治及制定慢性化预防策略提供依据。方法利用pEGX-4T-2/HCV-F融合载体表达蛋白HCV-F/GST作为抗原,包被酶联反应板,ELISA间接法检测362例HCV感染者及50例正常人血清HCV-F抗体,结合其人口学特征和疾病特征,统计分析HCV-F抗体的分布情况及与HCV感染的关系。结果 362例感染HCV的吸毒者F抗体阳性率为31.5%。通过比较发现F抗体阳性率在性别、吸毒时间、吸毒方式等因素中分布无统计学差异,而F抗体阳性率与年龄、联合感染可能具有一定关联。结论南京市吸毒人群HCV感染者中存在F抗体,其可能与疾病病程相关。更多还原

【Abstract】 Objective To assess the prevalence of serum anti-F in patients with hepatitis C virus(HCV) infection and the distribution of anti-F.In order to provide a basis for prevention and control of chronic hepatitis C.Methods The recombinant protein(HCV-F/GST) was coated onto micro titer plates as antigen.Sera of 362 drug users with hepatitis C virus infection and 50 normal sera were tested by indirect ELISA for detecting anti-F.Results 114 samples out of the 362(31.5%) HCV infected patients exhibited a positive anti-F reaction.Data from logistic analysis showed that the positive rate of anti-F was higher in drug users over 30 years old,coinfection with HIV or HBV.Conclusions Anti-F might be related to the progression of HCV infection.更多还原