【摘要】 目的为了寻找干扰核酸代谢的抗肿瘤新药,设计和合成嘌呤生物碱的类似物—吡唑[3,4-e]并-1,2,3,4-四嗪衍生物是有意义的。方法以3-甲基-5-氨基-1H-吡唑为原料,经过重氮化、偶合和分子内关环合成目标化合物3-甲基-5-芳基吡唑[3,4-e]并-1,2,3,4-四嗪衍生物。结果合成了八个新的嘌呤类似物。结论所得化合物,通过IR、~1H-NMR、元素分析和质谱分析证实为目标化合物。更多还原

【Abstract】 Objective In order to search the new anti-cancer drugs that disturb nucleic acid metabolizing,we designed and synthesized purine base analogues—pyrazole[3,4-e][1,2,3,4]tetrazines which is significative.Methods The objective compounds—5-aryl-3-methylpyrazole[3,4-e][1,2,3,4]tetrazines were synthesized via diazotization,coupling and intramolecular cyclization,using 5-amino-3-methyl-1-H-pyrazoles as materials.Result Eight new purine analogues were synthesized.Conclusion The resulting compounds were all identical to the objective compounds by IR,~1H-NMR,MS and element analysis.更多还原