【摘要】 目的探讨显微镜下经鼻蝶入路切除垂体腺瘤的临床疗效。方法回顾性分析了近两年来本科采用显微镜下经鼻蝶入路垂体腺瘤切除术治疗90例垂体腺瘤的临床资料,对肿瘤大小、类型、及切除范围与临床疗效的关系进行总结和分析。结果全部病例均经鼻蝶入路,手术全切治愈率为81.3%,显著高于次全切除(48.6%)和部分切除(10%),差异均具有显著性(P<0.05);次全切与部分切除相比差异无显著性(P>0.05)。垂体微腺瘤的治愈率为86%,显著高于垂体大腺瘤(52.6%)和垂体巨大腺瘤(44.4%),差异具有显著性(P<0.05);大腺瘤治愈率与巨大腺瘤间差异无显著性(P>0.05)。无功能垂体腺瘤与GH瘤、ACTH腺瘤比较,前者治愈率均低于后二者,差异具有显著性(P<0.05)。结论显微镜下经鼻蝶入路垂体腺瘤切除术,具有损伤小、术后并发症和死亡率低,术后康复时间短等优点,是一种安全有效的手术方式。更多还原

【Abstract】 Objective To explore the curative effect of transsphenoidal microsurgery on pituitary adenomas. Methods The clinical data of 90 patients with pituitary adenomas,who underwent the transsphenoidal microsurgery for pituitary adenomas during the past 2 years in our department,were reviewed.The relationship between the tumor size,type,resection scope and clinic efficacy were sumarized and analysed.Results 90 patients with pituitary adenomas were resected by microsurgery through transsphenoidal approach,the total resection cure rate(81.3%) was significantly higher than the sub-total resection(48.6%) and partial resection(10%),and the difference has statistical significance(P<0.05);the sub-total resection and partial resection has no statistical significance(P>0.05);the cure rate of micro-adenom was higher than macro-adenom and giantadenoma,and the difference has statistical significance(P<0.05);the macro-adenom and giant adenoma has no statistical significance(P>0.05);compared with GH adenoma and ACTH adenoma,the cure rate of adenoma without function was lower,and the difference has statistical significance(P<0.05). Conclusion The microsurgery through transsphenoidal approach for the pituitary adenomas had advantages such as minimal invasion,few complications,low mortality rate and a short recovery time.It is a safe and effective surgical method.更多还原