【摘要】 目的探讨无创正压通气(NIPPV)在治疗慢性阻塞性肺疾病急性加重期(AECOPD)并Ⅱ型呼吸衰竭的疗效。方法收集2006年3月~2008年12月本院呼吸内科住院的94例AECOPD患者,随机分为观察组(NIPPV)60例和对照组(非机械通气,NMV组)34例,观察二组治疗前后的动脉血气、住院病程及需气管插管率的变化。结果两组患者治疗前的基础情况差异无显著性(P>0.05),治疗组和对照组在治疗结束时pH、PaCO2、PaO2与治疗前均有明显改善(P<0.05)。治疗组住院病程、气管插管率明显降低,同非NIPPV治疗的对照组比较差异有显著性(P<0.05)。结论 NIPPV是治疗COPD急性加重期并发Ⅱ型呼吸衰竭的一种有效方法。更多还原

【Abstract】 Objective To investigate the effect of non-invasive positive pressure ventilation(NIPPV) for chronic obstructive pulmonary disease(COPD) and acute exacerbation of type II respiratory failure. Methods Collected from March 2006 to December 2008,department of respiratory medicine in our hospital,94 cases of hospitalized patients with AECOPD,were randomly assigned into observation group(NIPPV)(60 patients),and control group(NMV)(34 cases),and the change of arterial blood gas,hospitalization and tracheal intubation of two groups were observed in before and after treatment.Results There was no significant difference(P> 0.05)between pre-treatment basic situations of two groups.At the end of treatment,treatment group and control group showed significant improvement among pH,PaCO2,PaO2 compared with before treatment,the difference was significant(P<0.05).In treatment group,hospitalization,tracheal intubation was significantly reduced and different from the control group not treated by NIPPV(P>0.05). Conclusions NIPPV is an effective treatment of acute exacerbations of COPD complicated by respiratory failure Ⅱ.It can prevent the further development of disease(P<0.05).更多还原