【摘要】 目的探讨血管内皮生长因子C(VEGF-C)及D2-40在结肠癌中的表达及临床意义。方法取85例人结肠癌组织样本,应用免疫组织化学法,检测VEGF-C及D2-40的表达,并与其临床特征作相关分析。结果85例结肠癌组织中VEGF-C阳性表达率(54.1%)及微淋巴管数量(LMVD)与正常结肠组织间差异有显著性意义,且与淋巴结转移和临床分期相关,而与患者的年龄、性别、大小、浸润深度和分化程度无关,VEGF-C的表达与LMVD呈正相关(r=0.543,P<0.05)。结论结肠癌中VEGF-C的高表达与淋巴管生成、淋巴结转移和预后有关,联合检测VEGF-C和D2-40的表达对判断结肠癌的早期淋巴道转移、预后及指导临床治疗有重要的意义。更多还原

【Abstract】 Objective To approach the relationship between VEGF-C and D2-40 expressions in colon carcinoma and their association with clinicopathologic features.Methods The expressions of VEGF-C and D2-40 in 85 samples of colon cancer tissues were analyzed with immunohistochemistry. Results Of the 85 specimens,the positive expression of VEGF-C(54.1%) and Lymphatic vessel density(LMVD) were signifieantly higher than those in normal colonic tissues(P<0.05),and were correlated to lymph node metastasis and Duke’s stage(P<0.05) and non-correlated to age,sex,tumour size and the depth of invasion.While the expression of VEGF-C was positively correlated to the LMVD of the tumor(r=0.543,P<0.05).Conclusion The overexpresion of VEGF-C may be involved in generative of lympgatic vessel,nodal metastasis and prognosis.VEGF-C and D2-40 could serve as the joint detection of early clinical evaluation of lymphatic cancer metastasis as an important indicator and had important significance for the prognostic evaluation and treatment.更多还原