【摘要】 目的分析幽门螺杆菌(Helicobacter pylori,HP)根除治疗失败相关因素,为有效根除Hp提供建议和决策。方法对2005年5月2008年12月经胃镜检查确诊的慢性胃炎或消化性溃疡,且Hp检测阳性并行含质子泵抑制剂三联或四联治疗的患者103例进行研究。治疗结束至少4周后,用14C呼气试验评估Hp是否成功根除,根据测试结果分为治疗失败组33例及治疗成功组70例。运用统一标准的调查表对每位患者进行相关因素调查,就调查表所涉及的因素在根除失败组与成功组间采用单因素及多因素Logistic回归进行分析。结果通过单因素分析依从性和饮酒在两组之间有统计学意义(P<0.05)。Logistic多因素分析发现,依从性差是根除失败的独立危险因素。结论依从性差是治疗失败十分重要的影响因素。更多还原

【Abstract】 Objective To evaluate related factors associated with treatment failure of Helicobacter pylori (Hp) in order to obtain the effective measure for eradication treatment.Methods The Hp positive patients with chronic gastritis or peptic ulcer by gastroscopy were treated with proton pump inhibitors (PPI). ~14C-urea breath test was performed to evaluate the success of Hp eradication.All 103 subjects were divided into failed eradication group (n=33) and successful eradication group (n=70) according to the result of ~14C-urea breath test. All subjects completed questionnaire by self-designed register related factors for treatment failure.The univariate and multivariate logistic regression analyses were performed. Results According to univariate analysis,there were significant differences between two groups in compliance and alcohol consumption.According to multivariate logistic regression, poor compliance was an independent risk factor in treatment failure. Conclusion Poor compliance may be a significant factor for treatment failure.更多还原