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脂质组成对硫辛酸脂质纳米粒的制备及其稳定性的影响

Effect of Lipid Matrix on the Preparation and Stability of α-Lipoic Acid Loaded Nanostructured Lipid Carriers

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【Author】 Zou Aihua1,Zheng Kai1,Xia Qiang2,3,Ye Ruqiang1,Mu Bozhong1(1Institute of Applied Chemistry,East China University of Science and Technology,Shanghai,200237;2 School of Biological Science & Medical Engineering,Southeast University,Nanjing,210096;3 Suzhou Key Laboratory of Biomedical Materials and Technology,Southeast University,Suzhou,215123 )

【机构】华东理工大学应用化学研究所；东南大学生物科学与医学工程学院；东南大学苏州市生物医用材料与技术重点实验室；

【摘要】采用高压均质法制备硫辛酸(ALA)脂质纳米粒(ALA-NLC),确定了负载ALA的最佳体系。通过高效液相色谱、动态光散射、流变等测试研究了脂质成分、含量对ALA负载、ALA-NLC稳定性和分散液流变性质的影响,并用原子力显微镜观察了ALA-NLC的形貌。结果表明,脂质/ALA质量比在4.5∶1～6∶1之间,得到的脂质纳米粒分散均匀,颗粒规则;脂质中液态油脂的增加有利于保持ALA-NLC的粒径,储存稳定性和分散液的低粘度,并得到两个有望用于食品工业的ALA-NLC配方。更多还原

【Abstract】 Nanostructured lipid carriers of α-lipoic acid(ALA-NLC ) were prepared by high pressure homogenization method.High efficiency liquid chromatography,dynamic light-scattering,rheological measurements were used to determine the lipid matrix effect on the load of ALA,stability of ALA-NLC and rheological property of ALA-NLC dispersions.The morphology of ALA-NLC was observed by AFM.The results showed that the ALA-NLC was the regular nanoparticle when the weight ratio of lipid matrix /ALA ranged between 4.5:1 and 6:1.Moreover,the increase of liquid lipid in the lipid matrix will lead to the improvement of the ALA load,the stability of NLC,and the lower viscosity of ALA-NLC dispersions.Two formulations for dietary supplement of ALA-NLC were obtained.更多还原

【关键词】脂质纳米粒；硫辛酸；脂质；高压均质；
【Key words】 Nanostructured lipid carriers(NLC )； α-Lipoic acid(ALA )； Lipid matrix； High pressure homogenization(HPH)；

【基金】科技部国际合作重大项目(2008DFB50060);教育部博士点新教师基金项目(200802511024)资助

【文献出处】化学通报 ,Chemistry , 编辑部邮箱 ,2010年05期

【分类号】R943
【被引频次】4
【下载频次】349

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