【摘要】 目的探讨血管内皮生长因子-C(VEGF-C)在口腔鳞状细胞癌(OSCC)组织中的表达情况及其与血管、淋巴管生成、淋巴结转移之间的关系。方法调查拥有完整临床病理资料的67例口腔鳞癌患者的手术切除标本,采用SP免疫组化技术检测VEGF-C的表达情况并分析其与微血管密度(MVD)、淋巴管密度(LVD)及其他临床病理指标的关系。结果晚期病例、淋巴结转移阳性病例的VEGF-C表达明显升高(P值分别为0.015和<0.001),而VEGF-C表达与患者性别、肿瘤部位、肿瘤分化程度无关(P>0.05)。VEGF-C高表达组的LVD明显高于VEGF-C低表达组(P=0.001),但两组间MVD无统计学差异(P=0.125)。此外,淋巴结转移阳性组的LVD明显高于淋巴结转移阴性组(P=0.026)。结论 VEGF-C可能主要通过参与诱导口腔鳞癌淋巴管生成促进淋巴结转移。更多还原

【Abstract】 Objective To study the expression of vascular endothelial growth factor-C(VEGF-C) in oral squamous cell carcinoma(OSCC) and its relation to angiogenesis, lymphangiogenesis, as well as lymph node metastasis. Methods Sixty-seven archival specimens from patients with oral squamous cell carcinoma were investigated, whose clinicopathologic data were completely conserved. Immunohistochemical staining was performed to detect the expression of VEGF-C, microvessel density(MVD), lymphatic vessel density(LVD). The correlations between VEGF-C expression and MVD, LVD, as well as other clinicopathological features were measured. Results Although no correlation between VEGF-C expression and tumor location, histological grade, or gender of the patients was observed(P>0.05), OSCC patients with more advanced clinical stages and lymph node metastasis were prone to have high expression of VEGF-C(P=0.015 and P<0.001, respectively). Cases with high-expression of VEGF-C also showed significantly more often higher LVD(P=0.001) but not MVD(P=0.125). In addition, cases with lymph node involvement presented higher LVD than other cases(P=0.026). Conclusion VEGF-C may promote lymph node metastasis by inducing lymphangiogenesis in OSCC.更多还原