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Caco-2细胞模型用于毒害污染物转运与吸收研究

Application of Caco-2 Cell Model to Transportation and Absorption of Toxic Substances

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【Author】 Wang Deqing1 Yu Yingxin1 Zhong Yufang1 Wu Minghong1 Sheng Guoying1,2 Fu Jiamo1,2(1.Institute of Environmental Pollution and Health,School of Environmental and Chemical Engineering,Shanghai University,Shanghai 200444,China;2.State Key Laboratory of Organic Geochemistry,Guangdong Key Laboratory of Environmental Resources Utilization and Protection,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China)

【机构】上海大学环境与化学工程学院环境污染与健康研究所；中国科学院广州地球化学研究所有机地球化学国家重点实验室,广东省环境资源利用与保护重点实验室；

【摘要】 Caco-2细胞来源于人类结肠癌细胞,其单层细胞模型常用于体外模拟肠道上皮细胞转运与吸收外源性物质的研究,并被广泛地应用于毒理学研究等方面。本文简要介绍了Caco-2单层细胞模型的培养、细胞特性及常用功能指标;详细综述了环境毒害污染物在Caco-2细胞中转运与吸收机制以及污染物细胞毒性对其转运与吸收的影响,并对Caco-2单层细胞模型在环境毒害污染物的人体健康风险评估中的应用进行了展望。更多还原

【Abstract】 The Caco-2 cell monolayer,isolated from human colon carcinoma,has been wildly used in toxicology study and used as a tool to study the intestinal uptake and transport processes of xenobiotic.We introduces the culture conditions,the basic characteristics and functional parameters of Caco-2 cell monolayer model in brief.The paper also discussed the application of Caco-2 cell monolayer model in studying the mechanism of intestinal transportation and absorption of environmental toxic substances and toxic effects of these substances on their intestinal transportation and absorption in detail.In addition,the application of Caco-2 cells in human health risk assessment for environmental toxic substances is prospected.更多还原

【关键词】 Caco-2细胞；体外实验；转运与吸收；毒害污染物；生物利用度；环境风险评估；
【Key words】 Caco-2 cells； in vitro test； transportation and absorption； toxic substances； bioavailability； environmental risk assessment；

【基金】国家自然科学基金重点项目(No.40830744);国家自然科学基金青年科学基金项目(No.20807026);上海市重点学科项目(No.S30109)资助

【文献出处】化学进展 ,Progress in Chemistry , 编辑部邮箱 ,2010年04期

【分类号】X503.1
【被引频次】10
【下载频次】558

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