【摘要】 目的探讨结肠黑变病(melanosis coli,MC)的年龄、性别特点及其与结肠息肉的关系。方法回顾分析266例MC患者的临床特点及其与结肠息肉的关系。结果MC男性检出率为0.819%,女性为1.764%(P<O.01)。男性在<40岁、40-60岁和>60岁三个年龄段的检出率分别为0.362%、0.892%和2.594%,三者间差异有极明显统计学意义(P<O.01)。女性在上述三个年龄段的检出率分别为1.713%、1.812%、1.826%,三者间差异无统计学意义(P>0.05)。男性在<40岁、40-60岁这两个年龄段的MC检出率明显低于女性(P<0.05);而>60岁时,男、女性的检出率差异无统计学意义(P>0.05)。MC患者与炎性息肉、管状腺瘤、绒毛状腺瘤、癌变的伴发率分别为78.57%、18.57%、2.86%和2.63%,与同期接受结肠镜检查者检出率无显著差异(P>0.05)。结论MC的发生和年龄、性别有关;年龄越大,检出率越高;女性检出率明显高于男性,可能与女性内分泌、激素水平有关。MC与结肠息肉、结肠癌的发生无相关性。更多还原

【Abstract】 Objective To investigate the age and gender features of melanosis coli(MC) and the relation between MC and colorectal polyps .Methods The clinical features of 266 cases with MC and the relation between MC and colorectal polyps were retrospectively analyzed. Results The detection rate of MC was 0.819% in the male and 1.764% in the female (P<0.01). The detection rate is variable in age specific. For males,<40,40-60,>60 is 0.362%、0.892% and 2. 594%,which is remarkably significant(P<0.01).But for females, it is 1.713%,1.812% and 1.826%, which is not different. In the age specifics of <40 and 40-60,males have more chance to be involved by MC than females(P<0. 05),but not for age>60(P>0.05). The detection rates of inflammatory polyps,tubular adenoma,villous adenoma and colorectal cancer in MC patients were 78.57% ,18.57%,2.86% and 8.97%,respectively, not significantly different from those in patients who received colonoscopy as a general precaution in the same period(P>0.05). Conclusion The detection rate of MC is connected with age and gender,which increases with age. The detection rate of females is much higherthan males. It is probably related to endocrine and hormone level of the felamale. The detection rates of MC is not correlated with colorectal polyps or colorectal cancer.更多还原